Description
KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias.More information, please visit the website: http://www.bocsci.com/description.asp?cas=1000669-72-6
- Inhibitor
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More about
Boc Sciences
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Year
Established
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- Industry / Manufacturer
Keywords
- BOC Sciences
Contact and location
- Linna Green
- +1 631 xxxxxxxx
- New York / | United States